Response of urinary bladder to cholinergic and adrenergic agents.

The pharmacologic response of bladder muscle strip of albino rabbits was studied in vitro. The effect of cholinergic and adrenergic agents and their antagonists were demonstrated with a log dose-response curve. Cholinergic receptors were abundant in detrusor muscle. While the excitory alpha adrenergic receptors existed in bladder neck, the inhibitory beta adrenergic receptors were predominant in detrusor muscle. The role of cholinergic and adrenergic receptors in detrusor muscle and bladder neck was discussed.